I'm of the mind that any Marvel character can be used in all-ages animation if they're used well (Punisher, Deadpool, Blade, Jessica Jones, etc) but it would be a lot trickier if they're supposed to be the main protagonist. With Deadpool, I think you can tone down the language and anything sexual but if you tone the violence and the regeneration down too much, you would end up with something that's not completely Deadpool.